The Bears ran for 206 yards and scored twice after halftime, but Abilene Christian drained the final 8:11 to win.
Anna Kathryn Harrell made 13 saves and Sakiko Manabe scored from long range as UCA left Abilene with a draw.
Three first-half goals and a Harrell shutout gave UCA a 3-0 win over Little Rock and its first league victory.
UCA kept the ball 39 minutes in a 34-7 loss, while Seminole fans stayed restless about head coach Mike Norvell.
Central Arkansas closes its season Saturday with Senior Day as the Bears host Abilene Christian at Estes Stadium